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Available Strain Details

 
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Strain Number: 01ST2 
Common Strain Name: Rb1 null 
Strain Nomenclature: B6.129S2(Cg)-Rb1tm1Tyj/Nci 
 
Release Category (Required for MTA form): B3 , D
Sample MTA for this strain
   
       
Strain Description: Mice homozygous for the Rb1tm1Tyj targeted mutation die in utero, apparently from a failure to efficiently produce erythrocytes in the liver. Heterozygous mice develop intermediate lobe pituitary tumors beginning at 8 months of age; C cell tumors of the thyroid are also common in this strain. Retinal tumors, which develop in RB(+/-) humans, have not been observed in this strain.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Retinoblastoma 1
  Gene Symbol: Rb1
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: B6.Cg 
  Approx. Generation: 27 
  Organ Site : All 
       
Cryopreservation Mating Scheme: C57BL/6NCr females x heterozygous males  
Genotyping Information: Protocol 1: Allele: Rb1  
       
Donating Investigator: Dr. Tyler  Jacks
Key Reference: Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. 1992. Effects of an Rb mutation in the mouse. Nature. 359:295-300. PMID: 1406933 [PubMED Abstract]
     
       
Ordering Information for Cryoarchived Strains - Order Form for Cryoarchived Strains

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