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| Strain
Number: |
01ST2 |
| Common
Strain Name: |
Rb1 null |
| Strain
Nomenclature: |
B6.129S2(Cg)-Rb1tm1Tyj |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Mice homozygous for the Rb1tm1Tyj targeted mutation die in utero, apparently from a failure to efficiently produce erythrocytes in the liver. Heterozygous mice develop intermediate lobe pituitary tumors beginning at 8 months of age; C cell tumors of the thyroid are also common in this strain. Retinal tumors, which develop in RB(+/-) humans, have not been observed in this strain. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Retinoblastoma 1
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Gene
Symbol: |
Rb1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.Cg |
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Approx.
Generation: |
22 |
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Organ
Site : |
All |
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Husbandry: |
Breeder pairs are supplied as a heterozygote (male or female) and a C57BL/6N mate. |
| Genotyping Information: |
Protocol 1: Allele: Rb1
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| Donating
Investigator: |
Dr. Tyler Jacks |
| Key
Reference: |
Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. 1992. Effects of an Rb mutation in the mouse.
Nature. 359:295-300.
PMID: 1406933
[PubMED
Abstract]
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