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| Strain
Number: |
01X62 |
| Common
Strain Name: |
Arf floxed |
| Strain
Nomenclature: |
B6.129-Cdkn2atm4Cjs |
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| Release
Category (Required for MTA form):
B1
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Arf-null mice are highly tumor prone. 80% succumb of cancer (43 % of sarcoma, 29% of lymphoma, 17% of carcinoma and 11% of tumors of the nervous system) by 12 months of age (mean latency for survival of 38 weeks) (Kamijo et al, Cancer Res 1999, 59: 2217-2222). The latency and the penetrance are shortened when the mice are irradiated, or treated with DMBA (Kamijo et al, Cancer Res 1999, 59: 2217-2222). To prevent unwanted tumorigenesis outside of the tissue of interest, we generated an Arf floxed line. By crossing this line with a transgenic line expressing Cre recombinase in specific tissues and/ or in an inducible manner, Arf could be deleted in specific tissues and/ or spatially and temporally |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Cyclin-dependent kinase inhibitor 2A
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Gene
Symbol: |
Cdkn2a
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
homo |
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Organ
Site : |
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Husbandry: |
Homozygous breeder pairs are provided. Average litter size is 8-10. |
| Genotyping Information: |
Protocol 1: Allele: Cdkn2a
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| Donating
Investigator: |
Dr. Charles Sherr |
| Key
Reference: |
Gromley A, Churchman ML, Zindy F, Sherr CJ.
Howard Hughes Medical Institute and Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. PMID: 19339492
[PubMED
Abstract]
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| Sponsoring Institute: |
HHMI, St. Jude Children's Research Hospital |
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