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Strain Number: 01X62 
Common Strain Name: Arf floxed 
Strain Nomenclature: B6.129-Cdkn2atm4Cjs/Nci 
 
Release Category (Required for MTA form): B1
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: Arf-null mice are highly tumor prone. 80% succumb of cancer (43 % of sarcoma, 29% of lymphoma, 17% of carcinoma and 11% of tumors of the nervous system) by 12 months of age (mean latency for survival of 38 weeks) (Kamijo et al, Cancer Res 1999, 59: 2217-2222). The latency and the penetrance are shortened when the mice are irradiated, or treated with DMBA (Kamijo et al, Cancer Res 1999, 59: 2217-2222). To prevent unwanted tumorigenesis outside of the tissue of interest, we generated an Arf floxed line. By crossing this line with a transgenic line expressing Cre recombinase in specific tissues and/ or in an inducible manner, Arf could be deleted in specific tissues and/ or spatially and temporally
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Cyclin-dependent kinase inhibitor 2A
  Gene Symbol: Cdkn2a
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: B6.129 
  Approx. Generation: homo 
  Organ Site :  
       
Husbandry: Homozygous breeder pairs are provided. Average litter size is 8-10.
Genotyping Information: Protocol 1: Allele: Cdkn2a  
       
Donating Investigator: Dr. Charles  Sherr
Key Reference: Gromley A, Churchman ML, Zindy F, Sherr CJ. Howard Hughes Medical Institute and Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. PMID: 19339492 [PubMED Abstract]
     
Sponsoring Institute: HHMI, St. Jude Children's Research Hospital  
       
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