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| Strain Number: | 01X66 | ||
| Common Strain Name: | Langerin-Cre | ||
| Strain Nomenclature: | B6.Cg-Tg(CD207-cre)1Dhka | ||
| Release Category (Required for MTA form): B1 , B2 , B3 , D | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | When bred onto a strain carrying a homozygous floxed gene, that gene is efficiently excised in virtually all epidermal Langerhans cells. The resulting phenotype depends of which gene is ablated. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | iCre | ||
| Transgene Symbol: | iCre | ||
| Promoter Name: | Langerin, human | ||
| Promoter Symbol: | Langerin | ||
| Current Genetic Background: | B6.Cg | ||
| Approx. Generation: | 2 | ||
| Organ Site : | Skin, epidermis, lymph no | ||
| Husbandry: | Breeder pairs are supplied as a hemizgyote (male or female) x wildtype C57BL/6 mate. Average litter size is 4-6. | ||
| Genotyping Information: | Protocol 1: Allele: Tg(CD207-cre)1Dhka | ||
| Donating Investigator: | Dr. Daniel Kaplan | ||
| Key Reference: | Kaplan et al. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med (2007) vol. 204 (11) pp. 2545-52 PMID: 17938236; PMCID: PMC2118472 [PubMED Abstract] | ||
| Related References: | Igyarto et al. Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol (2009) vol. 183 (8) pp. 5085-93; PMID: 19801524 [PubMED Abstract] | ||
| Sponsoring Institute: | K08 AR651092 (to Dan Kaplan), R01 HL66279 and R01 AR44077 (to M.J. Shlomchik) | ||
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