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Strain Number: 01X66 
Common Strain Name: Langerin-Cre 
Strain Nomenclature: B6.Cg-Tg(CD207-cre)1Dhka/Nci 
 
Release Category (Required for MTA form): B1 , D
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: When bred onto a strain carrying a homozygous floxed gene, that gene is efficiently excised in virtually all epidermal Langerhans cells. The resulting phenotype depends of which gene is ablated.
       
Mutation Information  
  Mutation Type: Transgenic 
  Gene Name:
  Gene Symbol:
  Transgene Name: iCre
  Transgene Symbol: iCre
  Promoter Name: Langerin, human 
  Promoter Symbol: Langerin 
  Current Genetic Background: B6.Cg 
  Approx. Generation:
  Organ Site : Skin, epidermis, lymph no 
       
Husbandry: Breeder pairs are supplied as a hemizgyote (male or female) x wildtype C57BL/6 mate. Average litter size is 4-6.
Genotyping Information: Protocol 1: Allele: Tg(CD207-cre)1Dhka  
       
Donating Investigator: Dr. Daniel  Kaplan
Key Reference: Kaplan et al. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med (2007) vol. 204 (11) pp. 2545-52 PMID: 17938236; PMCID: PMC2118472 [PubMED Abstract]
Related References: Igyarto et al. Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol (2009) vol. 183 (8) pp. 5085-93; PMID: 19801524 [PubMED Abstract]
     
Sponsoring Institute: K08 AR651092 (to Dan Kaplan), R01 HL66279 and R01 AR44077 (to M.J. Shlomchik)  
       
Ordering Information for Live Mice - Order Form for Live Mice

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