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| Strain
Number: |
01XA1 |
| Common
Strain Name: |
Apc1638 |
| Strain
Nomenclature: |
B6.129-Apctm1Rak |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a chain-termination mutation in amino acid 1638 (exon 15) of the Apc gene. Mice homozygous for this mutation are embryonic lethal. Heterozygous mice develop multiple colonic polyps, gastrointestinal adenomas and adenocarcinomas. Liver metastases has been observed. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Adenomatosis polyposis coli
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Gene
Symbol: |
Apc
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
16 |
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Organ
Site : |
GI |
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Cryopreservation Mating Scheme: |
C57BL/6NCr females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Apc
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| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM, Kucherlapati R. 1994. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A. 13:8969-73
PMID: 8090754
[PubMED
Abstract]
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