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| Strain
Number: |
01XA3 |
| Common
Strain Name: |
Msh3 null |
| Strain
Nomenclature: |
B6.129-Msh3tm1Rak |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
This strain carries a null mutation in the DNA mismatch repair gene Msh3. Cells from mice homozygous for this mutation have only a partial mismatch repair defect. Mice homozygous for this mutation have only a slightly elevated tumor incidence over wild type mice. When combined with Msh6 null mutation, the mice show cancer susceptibility that is similar to that seen in Mlh1 and Msh2 nulls. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
MutS homolog 3
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Gene
Symbol: |
Msh3
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
N10 |
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Organ
Site : |
GI |
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Cryopreservation Mating Scheme: |
C57BL/6 females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Msh3
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| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res. 2000 Feb 15;60(4):803-7. PMID: 10706084
[PubMED
Abstract]
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