|
|
|
| Strain Number: | 01XA4 | ||
| Common Strain Name: | Msh6 null | ||
| Strain Nomenclature: | B6.129-Msh6tm1Rak | ||
| Release Category (Required for MTA form): B | |||
| Animal Health Report in PDF Format | |||
| Strain Information in Cancer Models Database | |||
| Strain Description: | This strain carries a null mutation in the DNA mismatch repair gene Msh6. Cells from mice homozygous for this mutation are incapable of repairing single-nucleotide but are capable of repairing insertion/deletion mismatches. Homozygous mice die between 3 and 15 months of age as a result of various tumors, including those of the GI tract. | ||
| Mutation Information | |||
| Mutation Type: | Targeted | ||
| Gene Name: | MutS homolog 6 | ||
| Gene Symbol: | Msh6 | ||
| Transgene Name: | |||
| Transgene Symbol: | |||
| Promoter Name: | |||
| Promoter Symbol: | |||
| Current Genetic Background: | B6.129 | ||
| Approx. Generation: | N11 | ||
| Organ Site : | GI | ||
| Cryopreservation Mating Scheme: | C57BL/6 females x heterozygous males | ||
| Genotyping Information: |
Protocol 1: Allele: Msh6 |
||
| Donating Investigator: | Dr. Raju Kucherlapati | ||
| Key Reference: | Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, Kolodner R, Kucherlapati R. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. 1997. Cell. 91, 467-477 PMID: 9390556 [PubMED Abstract] | ||
 |
 |
 |