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| Strain
Number: |
01XA5 |
| Common
Strain Name: |
Msh2 null |
| Strain
Nomenclature: |
B6.129-Msh2tm1Rak |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
This strain carries a null mutation in the DNA mismatch repair gene Msh2. Cells from mice homozygous for this mutation are incapable of repairing single-nucleotide and insertion/deletion mismatches. Homozygous mice become moribund between 2.5 and 11.5 months, the result of lymphomas (about 70%) and/or intestinal tumors (about 70%). Heterozygous mice have a higher incidence of tumors than wild type mice, but live in excess of 16 months. This strain has been used to study the effect of this mismatch repair mutation on mice carrying Apc mutations. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
MutS homolog 2
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Gene
Symbol: |
Msh2
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
N10 |
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Organ
Site : |
GI |
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Cryopreservation Mating Scheme: |
C57BL/6 females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Msh2
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| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Smits R, Hofland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R. Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. 2000. Genes, Chromosomes & Cancer 23:229-23
PMID: 10992298
[PubMED
Abstract]
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