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Strain Number: 01XA9 
Common Strain Name: MMTV-Cre, Line F 
Strain Nomenclature: B6.Cg-Tg(MMTV-Cre)FMam/Nci 
 
Release Category (Required for MTA form): C1 , D
Sample MTA for this strain
   
       
Strain Description: Widespread Cre expression including the female germline. High levels of recombination in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin and cells of the immune system. Little expression in the lung, kidney, liver and brain. Females from this line display impaired mammary development and are unable to nurse successfully, so if used in the colony pups must be fostered. Refer to PMID 21255551 for details.
       
Mutation Information  
  Mutation Type: Transgenic 
  Gene Name:
  Gene Symbol:
  Transgene Name: Cre recombinase
  Transgene Symbol: Cre
  Promoter Name: Mouse mammary tumor virus 
  Promoter Symbol: MMTV 
  Current Genetic Background: B6.Cg 
  Approx. Generation: 28 
  Organ Site : Breast 
       
Cryopreservation Mating Scheme: C57BL/6NCr females x heterozygous males  
Genotyping Information: Protocol 2: Allele: Tg(MMTV-Cre)FMam  
       
Donating Investigator: Dr. Lothar  Hennighausen
Key Reference: Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, Li M, Furth PA, Hennighausen L 1997. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25 :4323-4330. PMID: 9336464 [PubMED Abstract]
Related References: Robinson GW, Hennighausen L. MMTV-Cre transgenes can adversely affect lactation: Considerations for conditional gene deletion in mammary tissue. Anal Biochem. 2011 Jan 19. PMID: 21255551 [PubMED Abstract]
     
       
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