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Strain Number: 01XAB 
Common Strain Name: ROSA-CreER 
Strain Nomenclature: B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Tyj/Nci 
 
Release Category (Required for MTA form): B3 , C4A , C4B , D
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: These mice carry a conditional cre recombinase (Cre-ERT2) allele targeted to the ubiquitously expressed ROSA26 locus (Thumpd3). The estrogen receptor T2 (ERT2) moiety fused to cre retains the recombinase in the cytosol until tamoxifen administration releases this inhibition, thus permitting inducible recombination of LoxP sites.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: gene trap ROSA 26, Philippe Soriano
  Gene Symbol: Gt(ROSA)26Sor
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: B6;129 
  Approx. Generation: 16 
  Organ Site : Various 
       
Husbandry: Homozygous breeder pairs are provided. Average litter size is 6.
Genotyping Information: Protocol 1: Allele: Gt(ROSA)26Sor  
       
Donating Investigator: Dr. Tyler  Jacks
Key Reference: Ventura, A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R and Jacks T. 2007. Restoration of p53 function leads to tumor regression in vivo. Nature. 2007 Feb 8;445(7128):606-7. PMID: 17251932 [PubMED Abstract]
     
Sponsoring Institute: Department of Defense W81XWH-05-1-0265, Howard Hughes Medical Insititute  
       
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