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Strain Number: 01XAC 
Common Strain Name: ROSA26-pCAGGs-LSL-Luciferase 
Strain Nomenclature: B6.129-Gt(ROSA)26Sortm2(ACTB-Luc)Tyj/Nci 
 
Release Category (Required for MTA form): B3 , D
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: A Cre-inducible luciferase transgene was targeted into the Rosa26 locus and is driven by a CMV-based promoter. This allele when used in combination with Cre-regulated oncogenes or tumor suppressors can allow for noninvasive detection of tumors in mice. This allele permits serial imaging of mice, thus increasing the utility of mouse tumor models as a system to test therapeutics.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: gene trap ROSA 26, Philippe Soriano
  Gene Symbol: Gt(ROSA)26Sor
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: B6.129 
  Approx. Generation: 16 
  Organ Site : Various 
       
Husbandry: Breeder pairs are supplied as a heterozygote (male or female) and C57BL/6 mate (male or female). Average litter size is 8. Homozygotes are viable but breed as heterozygotes for increased fertility.
Genotyping Information: Protocol 1: Allele: Gt(ROSA)26  
       
Donating Investigator: Dr. Tyler  Jacks
Key Reference:
     
Sponsoring Institute: Howard Hughes Medical Insititute, 5-U54-CA112967-03  
       
Ordering Information for Live Mice - Order Form for Live Mice

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