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| Strain
Number: |
01XAC |
| Common
Strain Name: |
ROSA26-pCAGGs-LSL-Luciferase |
| Strain
Nomenclature: |
B6.129-Gt(ROSA)26Sortm2(ACTB-Luc)Tyj |
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| Release
Category (Required for MTA form):
B3
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D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
A Cre-inducible luciferase transgene was targeted into the Rosa26 locus and is driven by a CMV-based promoter. This allele when used in combination with Cre-regulated oncogenes or tumor suppressors can allow for noninvasive detection of tumors in mice. This allele permits serial imaging of mice, thus increasing the utility of mouse tumor models as a system to test therapeutics. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
gene trap ROSA 26, Philippe Soriano
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Gene
Symbol: |
Gt(ROSA)26Sor
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
12 |
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Organ
Site : |
Various |
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Husbandry: |
Breeder pairs are supplied as a heterozygote (male or female) and C57BL/6 mate (male or female). Average litter size is 8. Homozygotes are viable but breed as heterozygotes for increased fertility. |
| Genotyping Information: |
Protocol 1: Allele: Gt(ROSA)26
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| Donating
Investigator: |
Dr. Tyler Jacks |
| Key
Reference: |
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| Sponsoring Institute: |
Howard Hughes Medical Insititute, 5-U54-CA112967-03 |
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