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| Strain Number: | 01XAE | ||
| Common Strain Name: | WAP-Tag | ||
| Strain Nomenclature: | B6.Cg-Tg(WapTag)8Gmn | ||
| Release Category (Required for MTA form): C,D | |||
| Strain Description: | These mice express SV40 T/t antigen under control of the lactotropic hormone-inducible whey acidic protein (Wap) promoter, which is specific for mammary gland epithelial (ME) cells. Females synthesize T/t antigen (Tag) in ME cells during pregnancy and the lactation period. Mice that undergo at least one pregnancy develop palpable mammary tumors (adenocarcinomas) at 6 months of age. Female transgenic mice cannot be used as breeders due to a lactation defect. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | SV40 Large T antigen | ||
| Transgene Symbol: | TAg | ||
| Promoter Name: | Wap (mouse) | ||
| Promoter Symbol: | Wap | ||
| Current Genetic Background: | B6.Cg | ||
| Approx. Generation: | |||
| Organ Site : | Mammary gland | ||
| Cryopreservation Mating Scheme: | C57BL/6 females x hemizygous males | ||
| Genotyping Information: | Protocol 1: Allele: Tg(WapTag)8Gmn | ||
| Donating Investigator: | Dr. Esta Sterneck | ||
| Key Reference: | Tzeng YJ, Guhl E, Graessmann M, Graessmann A. Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene. Oncogene 8, 1965-1971, 1993. PMID 8390039 [PubMED Abstract] | ||
| Related References: | Santarelli R, Tzeng YJ, Zimmermann C, Guhl E, Graessmann A. SV40 T-antigen induces breast cancer formation with a high efficiency in lactating and virgin WAP-SV-T transgenic animals but with a low efficiency in ovariectomized animals. Oncogene 12, 495-505, 1996. PMID 8637705. [PubMED Abstract] | ||
| Tzeng YJ, Gottlob K, Santarelli R, Graessmann A. The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice. FEBS Lett 19, 215-218, 1996. PMID 8601427 Tzeng YJ, Gottlob K, Santarelli R, Graessmann A. The SV40 T-antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice. FEBS Lett 19, 215-218, 1996. PMID 8601427 [PubMED Abstract] | |||
| Tzeng YJ, Zimmermann C, Guhl E, Berg B, Avantaggiati ML, Graessmann A. SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors. Oncogene 16, 2103-2114, 1998. PMID 9572491. [PubMED Abstract] | |||
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