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| Strain
Number: |
01XB2 |
| Common
Strain Name: |
Ink4a/Arf null |
| Strain
Nomenclature: |
FVB.129-Cdkn2atm1Rdp |
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| Release
Category (Required for MTA form):
C
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
This strain carries a targeted deletion of exons 2/3 of the INK4a/ARF locus which eliminates both p16 (Ink4a) and p19 (Arf). Mice homozygous for this deletion are viable and fertile, but exhibit a cancer-prone condition. On a mixed genetic background, spontaneous development of various tumors (primarily B-cell lymphomas and sarcomas) is observed by ~6 months of age. Tumors arisen in mice heterozygous for this deletion require a longer latency and uniformly demonstrate loss-of-heterozygosity of the second allele. On FVB/n background, tumor latency is shortened. In addition to the tumor phenotype, these mice, by two months of age, histologically exhibit mild proliferative expansion of the white and red pulp of the spleen. Mice older than 6 months develop more severe extramedullary hematopoesis in the spleen and other lymphoid organs such as the liver. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Cyclin-dependent kinase inhibitor 2A
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Gene
Symbol: |
Cdkn2a
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
FVB.129 |
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Approx.
Generation: |
homo |
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Organ
Site : |
All |
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Husbandry: |
Homozygous breeder pairs are provided. |
| Genotyping Information: |
Protocol 1: Allele: Cdkn2a
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| Donating
Investigator: |
Dr. Ron DePinho |
| Key
Reference: |
Manuel Serrano, Han-Woong Lee, Lynda Chin, Carlos Cordon-Cardo, David Beach, and Ronald A. DePinho
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
Cell 1996 85: 27.
PMID: 8620534
[PubMED
Abstract]
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