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| Strain
Number: |
01XB3 |
| Common
Strain Name: |
Nkx3.1 null |
| Strain
Nomenclature: |
B6;129-Nkx3-1tm1Mms |
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| Release
Category (Required for MTA form):
B
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
This strain carries a targeted null mutation in the Nkx3-1 (Nkx3.1) gene, which appears to function as a tumor suppressor gene in the prostate. Homozygous males display prostatic epithelial hyperplasia and dysplasia that increases with age. Heterozygous mice display a similar, less severe, phenotype, indicating haploinsufficiency. There are also defects in prostate ductal morphogenesis and secretory protein production. There is no reported female phenotype. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
NK-3 transcription factor, locus 1 (Drosophilia)
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Gene
Symbol: |
Nkx3-1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6;129 |
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Approx.
Generation: |
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Organ
Site : |
Prostate |
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Cryopreservation Mating Scheme: |
C57BL/6 females x homozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Nkx3.1
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| Donating
Investigator: |
Dr. Cory Abate-Shen |
| Key
Reference: |
Rajula Bhatia-Gaur, Annemarie A. Donjacour, Peter J. Sciavolino, Minjung Kim, Nishita Desai, Peter Young, Christine R. Norton, Thomas Gridley, Robert D. Cardiff, Gerald R. Cunha, Cory Abate-Shen, and Michael M. Shen. 1999; Roles for Nkx3.1 in prostate development and cancer.
Genes Dev. 13:966-77.
PMID: 10215624
[PubMED
Abstract]
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