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| Strain
Number: |
01XBC |
| Common
Strain Name: |
N-ras null, Nras KO |
| Strain
Nomenclature: |
B6;129P2-Nrastm1Rak |
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| Release
Category (Required for MTA form):
B
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| Strain
Description: |
This strain carries a null mutation in N-ras, one of three highly homologous and widely expressed members of the ras family. Mice homozygous for this mutation develop normally (Umanoff et al., 1995). When combined with K-ras heterozygosity, mice exhibit abnormal hematopoietic development and die between days 10 and 12 of embryogenesis (Johnson et al., 1997). |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
neuroblastoma ras oncogene
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Gene
Symbol: |
Nras
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6;129 |
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Approx.
Generation: |
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Organ
Site : |
hematopoietic |
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Cryopreservation Mating Scheme: |
C57BL/6 females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Nras
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| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Umanoff H, Edelmann W, Pellicer A, Kucherlapati R. The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci USA 92, 1709-1713, 1995. PMID: 7878045
[PubMED
Abstract]
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| Related
References: |
Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev 11, 2468-2481, 1997. PMID: 9334313 [PubMED
Abstract] |
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| Sponsoring Institute: |
NIH HG00380, American Cancer Society CN-132, NCI CA13330, NIH T32NS07183, Deutsche Forschungsgemeinschaft |
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