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| Strain Number: | 01XBH | ||
| Common Strain Name: | LANA | ||
| Strain Nomenclature: | B6.129-Tg(HHV8ORF73,Tk-GFP)1Dtmr | ||
| Release Category (Required for MTA form): B | |||
| Strain Description: | Kaposi sarcoma-associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANA's contribution to lymphomagenesis in vivo we generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM+ IgD+ B cells and showed increased germinal center formation. We also observed lymphomas (latency 300 days), implying that LANA can activate B cells and provide the first step toward lymphomagenesis. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | LANA | ||
| Transgene Symbol: | LANA | ||
| Promoter Name: | LANA, KSHV (viral) | ||
| Promoter Symbol: | LANA, KSHV | ||
| Current Genetic Background: | B6.129 | ||
| Approx. Generation: | |||
| Organ Site : | Hematopoietic | ||
| Cryopreservation Mating Scheme: | C57BL/6 females x hemizygous males | ||
| Genotyping Information: | Protocol 1: Allele: Tg(HHV8ORF73, Tk-GFP)1Dtmr | ||
| Donating Investigator: | Dr. Dirk Dittmer | ||
| Key Reference: | Fakhari FD, Jeong JH, Kanan Y, Dittmer DP. The latency-associated nuclear antigen of Kaposis sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma. J Clin Invest 3, 735-742, 2006. PMID: 16498502 [PubMED Abstract] | ||
| Sponsoring Institute: | NIH R01 CA109232-03 | ||
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