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| Strain
Number: |
01XBM |
| Common
Strain Name: |
Pax3:Fkhr conditional knock-in |
| Strain
Nomenclature: |
B6;129-Pax3tm1Mrc |
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| Release
Category (Required for MTA form):
C1
,
D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
Germline activation leads to exencephaly; Cre activation in muscle lineages leads to alveolar rhabdomyosarcoma tumors. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Paired-box 3
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Gene
Symbol: |
Pax3
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6;129 |
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Approx.
Generation: |
homo |
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Organ
Site : |
Any tissue |
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Husbandry: |
Breeder pairs are supplied as homozygotes. Average litter size is 6-8. Donating investigator recommends maintaining stock breeders as homozygous without Cre. |
| Genotyping Information: |
Protocol 1: Allele: Pax3
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| Donating
Investigator: |
Dr. Charles Keller |
| Key
Reference: |
Keller C, Hansen MS, Coffin CM, Capecchi MR.
Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA.
Pubmed ID 15520281
[PubMED
Abstract]
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| Related
References: |
Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR.
Division of Pediatric Hematology-Oncology and Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA.
Pubmed ID 15489287
[PubMED
Abstract] |
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