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| Strain
Number: |
01XBQ |
| Common
Strain Name: |
Nkx3.1-CreERT2 |
| Strain
Nomenclature: |
B6;129S-Nkx3-1tm4(cre/ERT2)Mms |
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| Release
Category (Required for MTA form):
C4A
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C4B
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This allele is a knock-in of an inducible Cre recombinase into the Nkx3.1 locus (and is a null allele), and can be used for inducible gene targeting in the prostate epithelium.
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
NK-3 transcription factor, locus 1 (Drosophilia)
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Gene
Symbol: |
Nkx3-1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6;129S |
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Approx.
Generation: |
4 |
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Organ
Site : |
Prostate |
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Husbandry: |
Breeder pairs are supplied as homozygotes. Homozygous males should be bred at a young age (within the first 4-5 months). Occasionally, if not bred early on, they do not mate; some homozygous males never breed. If there is a breeding cage that has not had pups for 2 months, the male should be removed and a new one put in. Once they start breeding they do fine. Average litter size is 6-8. |
| Genotyping Information: |
Protocol 1: Allele: Nkx3-1
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| Donating
Investigator: |
Dr. Michael Shen |
| Key
Reference: |
Wang, X., Kruithof-de Julio, M., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C., and Shen, M. M. (2009). A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461: 495-500. PMID: 19741607
[PubMED
Abstract]
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| Sponsoring Institute: |
U01 CA084294 (NCI Mouse Models of Human Cancers Consortium), R01 DK076602 |
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