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Strain Number: 01XBQ 
Common Strain Name: Nkx3.1-CreERT2 
Strain Nomenclature: B6;129S-Nkx3-1tm4(cre/ERT2)Mms/Nci 
 
Release Category (Required for MTA form): C4A , C4B
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: This allele is a knock-in of an inducible Cre recombinase into the Nkx3.1 locus (and is a null allele), and can be used for inducible gene targeting in the prostate epithelium.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: NK-3 transcription factor, locus 1 (Drosophilia)
  Gene Symbol: Nkx3-1
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: B6;129S 
  Approx. Generation:
  Organ Site : Prostate 
       
Husbandry: Breeder pairs are supplied as homozygotes. Homozygous males should be bred at a young age (within the first 4-5 months). Occasionally, if not bred early on, they do not mate; some homozygous males never breed. If there is a breeding cage that has not had pups for 2 months, the male should be removed and a new one put in. Once they start breeding they do fine. Average litter size is 6-8.
Genotyping Information: Protocol 1: Allele: Nkx3-1  
       
Donating Investigator: Dr. Michael  Shen
Key Reference: Wang, X., Kruithof-de Julio, M., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C., and Shen, M. M. (2009). A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461: 495-500. PMID: 19741607 [PubMED Abstract]
     
Sponsoring Institute: U01 CA084294 (NCI Mouse Models of Human Cancers Consortium), R01 DK076602  
       
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