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| Strain
Number: |
01XC1 |
| Common
Strain Name: |
Rb floxed |
| Strain
Nomenclature: |
FVB;129-Rb1tm2Brn |
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| Release
Category (Required for MTA form):
C,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a conditional mutation in the endogenous Rb1 gene. LoxP sites were inserted into introns surrounding exon 19 in the Rb1 locus. Removal of the region flanked by the LoxP sites results in mice with the same tumor spectrum as mice with a conventional Rb1-null mutation. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Retinoblastoma 1
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Gene
Symbol: |
Rb1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
FVB;129 |
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Approx.
Generation: |
homo |
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Organ
Site : |
All |
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Husbandry: |
Homozygous breeder pairs are provided. |
| Genotyping Information: |
Protocol 1: Allele: Rb1
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| Donating
Investigator: |
Dr. Anton Berns |
| Key
Reference: |
Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev.14:994-1004.
PMID: 10783170
[PubMED
Abstract]
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