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Available Strain Details

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Strain Number: 01XC2 
Common Strain Name: p53 floxed 
Strain Nomenclature: FVB.129P2-Trp53tm1Brn/Nci 
Release Category (Required for MTA form): C2 , D
Sample MTA for this strain
Animal Health Report in PDF Format  
Strain Description: This strain carries a conditional mutation in the endogenous p53 gene (Trp53). LoxP sites were inserted into intron 1 and intron 10 of the p53 locus. Homozygous mice were monitored for one year with no increased tumor incidence over wild type controls. Crosses to mice expressing Cre in the germline show the same tumor spectrum as do conventional p53-null mice.
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Transformation related protein 53
  Gene Symbol: Trp53
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: FVB.129 
  Approx. Generation: 25 
  Organ Site : various 
Husbandry: Heterozygous breeder pairs are provided.
Genotyping Information: Protocol 1: Allele: Trp53  
Donating Investigator: Dr. Anton  Berns
Key Reference: Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 29(4):418-25. PMID: 11694875 [PubMED Abstract]
Related References: Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14:994-1004. PMID: 10783170 [PubMED Abstract]
Ordering Information for Live Mice - Order Form for Live Mice

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