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| Strain
Number: |
01XC2 |
| Common
Strain Name: |
p53 floxed |
| Strain
Nomenclature: |
FVB.129-Trp53tm1Brn |
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| Release
Category (Required for MTA form):
C2
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D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a conditional mutation in the endogenous p53 gene (Trp53). LoxP sites were inserted into intron 1 and intron 10 of the p53 locus. Homozygous mice were monitored for one year with no increased tumor incidence over wild type controls. Crosses to mice expressing Cre in the germline show the same tumor spectrum as do conventional p53-null mice. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Transformation related protein 53
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Gene
Symbol: |
Trp53
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
FVB.129 |
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Approx.
Generation: |
22 |
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Organ
Site : |
various |
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Husbandry: |
Heterozygous breeder pairs are provided. |
| Genotyping Information: |
Protocol 1: Allele: Trp53
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| Donating
Investigator: |
Dr. Anton Berns |
| Key
Reference: |
Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
Nat Genet. 29(4):418-25.
PMID: 11694875
[PubMED
Abstract]
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| Related
References: |
Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14:994-1004.
PMID: 10783170 [PubMED
Abstract] |
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