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| Strain
Number: |
01XC3 |
| Common
Strain Name: |
Ahr null |
| Strain
Nomenclature: |
B6.129-Ahrtm1Gonz |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Information in Cancer Models Database |
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| Strain
Description: |
Livers of Ahr(-/-) mice are about 50% the size of normal livers and exhibit hepatic portal hypertension. Mice have enlarged hearts (cardiomyopathy). There is decreased accumulation of B lymphocytes in the lymph nodes and spleen but the thymus is normal. Ahr(-/-) mice are unresponsive to dioxin-induced catabolism of foreign compounds. They also have higher incidences of liver tumors and gastric polyps than do wild-type mice. Although about half of the original homozygous Ahrtm1Gonz (Ahr -/-) mice died shortly after birth the survivors reached maturity and were fertile. Breeding these survivors produces 100% survival of littermates, the neonatal phenotype apparently being lost. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Aryl-hydrocarbon receptor
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Gene
Symbol: |
Ahr
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
B6.129 |
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Approx.
Generation: |
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Organ
Site : |
GI, Skin |
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Cryopreservation Mating Scheme: |
Wild-type (C57BL/6NCr) females x heterozygous males |
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| Genotyping Information: |
Protocol 2: Allele: Ahr
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| Donating
Investigator: |
Dr. Jerrold Ward |
| Key
Reference: |
Fernandez-Salguero P, Pineau T, Hilbert DM, McPhail T, Lee SS, Kimura S, Nebert DW, Rudikoff S, Ward JM, Gonzalez FJ. 1995. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science.268:722-6.
PMID: 7732381
[PubMED
Abstract]
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