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| Strain
Number: |
01XC4 |
| Common
Strain Name: |
Brca1 null, Brca1 KO |
| Strain
Nomenclature: |
STOCK Brca1tm1Cxd |
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| Release
Category (Required for MTA form):
C
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a null mutation of Brca1. Homozygotes die at E7-8. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Breast cancer 1
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Gene
Symbol: |
Brca1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
STOCK |
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Approx.
Generation: |
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Organ
Site : |
Breast |
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Cryopreservation Mating Scheme: |
Wild-type non-sibling STOCK females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Brca1
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| Donating
Investigator: |
Dr. CX Deng |
| Key
Reference: |
Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX. 1998. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 17:3115-24.
[PubMED
Abstract]
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