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| Strain
Number: |
01XC8 |
| Common
Strain Name: |
Brca1 floxed |
| Strain
Nomenclature: |
STOCK Brca1tm2Cxd |
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| Release
Category (Required for MTA form):
C,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a conditional mutation of Brca1on a mixed genetic background involving >90% C57BL/6. Specifically, exon 11 is flanked with loxP sites. Mating this strain with any Cre transgenic strain will result in the inactivation of Brca1 wherever Cre is expressed. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Breast cancer 1
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Gene
Symbol: |
Brca1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
STOCK |
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Approx.
Generation: |
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Organ
Site : |
Breast |
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Husbandry: |
Homozygous breeder pairs are provided. |
| Genotyping Information: |
Protocol 1: Allele: Brca1
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| Donating
Investigator: |
Dr. CX Deng |
| Key
Reference: |
Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX. 1999. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
Nat Genet. 22:37-43.
PMID: 10319859
[PubMED
Abstract]
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