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| Strain
Number: |
01XC9 |
| Common
Strain Name: |
Brca1 Exon 11 del |
| Strain
Nomenclature: |
STOCK Brca1tm2.1Cxd |
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| Release
Category (Required for MTA form):
C
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| Animal Health Report in PDF Format |
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| Strain
Description: |
This strain carries a hypomorphic mutation of Brca1. Specifically, exon 11, which encodes 60% of the protein, has been deleted from the germline using a Cre-lox strategy. Homozygotes die at E12.5-18.5, however, can be rescued by the haploid loss of p53. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Breast cancer 1
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Gene
Symbol: |
Brca1
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
STOCK |
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Approx.
Generation: |
F6 |
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Organ
Site : |
Breast |
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Cryopreservation Mating Scheme: |
Wild-type STOCK females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Brca1
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| Donating
Investigator: |
Dr. CX Deng |
| Key
Reference: |
Xu X; Qiao W; Linke SP; Cao L; Li WM; Furth PA; Harris CC; Deng CX. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28, 266-271, 2001. PMID:11431698
[PubMED
Abstract]
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