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Strain Number: 01XF2 
Common Strain Name: Nf1 null (129) 
Strain Nomenclature: 129-Nf1tm1Fcr/Nci 
 
Release Category (Required for MTA form): B1
Sample MTA for this strain
   
       
Strain Description: Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function (Costa RM et.al. 2001. Nature).
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Neurofibromatosis 1
  Gene Symbol: Nf1
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: 129 
  Approx. Generation: F6 
  Organ Site :  
       
Cryopreservation Mating Scheme: 129S1/SvImJ/Cr females x heterozygous males  
Genotyping Information: Protocol 1: Allele: Nf1  
       
Donating Investigator: Dr. Luis  Parada
Key Reference: Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev 8:1019-1029. PMID: 7926784 [PubMED Abstract]
     
       
Ordering Information for Cryoarchived Strains - Order Form for Cryoarchived Strains

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