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Strain Number: 01XGL 
Common Strain Name: ED-L2/Cre  
Strain Nomenclature: B6.Cg-Tg(ED-L2-cre)267Jkat/Nci 
 
Release Category (Required for MTA form): B2
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: Cre expression in epithelia of tongue, esophagus, forestomach, with some expresion in ventral neck skin but otherwise no expression in skin. Thus, these mice may be especially useful when gene deletion in skin is lethal.
       
Mutation Information  
  Mutation Type: Transgenic 
  Gene Name:
  Gene Symbol:
  Transgene Name: Cre recombinase
  Transgene Symbol: Cre
  Promoter Name: ED-L2, origin Ebstein Barr Virus (EBV) 
  Promoter Symbol: ED-L2 
  Current Genetic Background: B6.Cg 
  Approx. Generation:
  Organ Site : Tongue, esophagus stomach 
       
Husbandry: Breeder pairs are supplied as a hemizygote (male or female) x wildtype C57BL/6 mate. Average litter size is 8.
Genotyping Information: Protocol 1: Allele: Tg(ED-L2-cre)267Jkat  
       
Donating Investigator: Dr. Jonathan  Katz
Key Reference: Tetreault MP, Yang Y, Travis J, Yu QC, Klein-Szanto A, Tobias JW, Katz JP. Esophageal Squamous Cell Dysplasia and Delayed Differentiation With Deletion of Kr├╝ppel-Like Factor 4 in Murine Esophagus. Gastroenterology. 2010 Mar 27. [Epub ahead of print]. PMID: 20347813 [PubMED Abstract]
Related References: Nakagawa H, Wang TC, Zukerberg L, Odze R, Togawa K, May GH, Wilson J, Rustgi AK.The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene. 1997 Mar 13;14(10):1185-90. PMID: 9121767 [PubMED Abstract]
     
Sponsoring Institute: NIH NIDDK R01 DK069984 NIH NIDDK P30 DK050306 NIH NCI P01 CA098101  
       
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