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| Strain Number: | 01XJ7 | ||
| Common Strain Name: | Akt1, MPAKT | ||
| Strain Nomenclature: | FVB-Tg(Pbsn-AKT1)9Wrs | ||
| Release Category (Required for MTA form): B,D | |||
| Animal Health Report in PDF Format | |||
| Strain Description: | Akt Expression and Activation is sufficient for the induction of prostate intraepithelial neoplasia (PIN). Histologic study of the ventral prostate of the Murine Prostate restricted Akt Kinase Transgenic mice (MPAKT) revealed a striking phenotype characterized by a hyperplastic and dysplastic epithelium with disorganized multi-cell layers, intraepithelial lumen formation, loss of cell polarity, nuclear atypia and apoptotic bodies. These histopathologic features are consistent with PIN. | ||
| Mutation Information | |||
| Mutation Type: | Transgenic | ||
| Gene Name: | |||
| Gene Symbol: | |||
| Transgene Name: | Mouse thymoma viral proto-oncogene 1 | ||
| Transgene Symbol: | Akt1 | ||
| Promoter Name: | Probasin | ||
| Promoter Symbol: | Pb | ||
| Current Genetic Background: | FVB | ||
| Approx. Generation: | |||
| Organ Site : | Prostate | ||
| Cryopreservation Mating Scheme: | FVB/N females x hemizygous males | ||
| Genotyping Information: | Protocol 1: Allele: Tg(Pb-Akt1)Ak9Wrs | ||
| Donating Investigator: | William R. Sellers | ||
| Key Reference: | Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR, Loda M, Sellers WA. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci USA 100, 7841-7846, 2003. PMID: 12799464. [PubMED Abstract] | ||
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