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Strain Number: 01XL9 
Common Strain Name: p53 R172H 
Strain Nomenclature: 129S4-Trp53tm2.1Tyj/Nci 
 
Release Category (Required for MTA form): B3 , D
Sample MTA for this strain
   
       
Strain Description: These mice express point-mutant p53 under control of the endogenous Trp53 promoter. Heterozygous mice have an increased tumor burden relative to Trp53+/- mice but similar survival curves. The animals show a broad tumor spectrum with an increased frequency of carcinomas, osteosarcomas, hemangiosarcomas, and lymphoblastic lymphomas. Osteosarcomas are more frequently metastatic. An improved model for Li-Fraumeni Syndrome.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Transformation related protein 53
  Gene Symbol: Trp53
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: 129S4 
  Approx. Generation:
  Organ Site : multiple 
       
Cryopreservation Mating Scheme: 129S4 females x heterozygous males  
Genotyping Information: Protocol 1: Allele: Trp53  
       
Donating Investigator: Dr. Tyler  Jacks
Key Reference: Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60. PMID: 15607980 [PubMED Abstract]
     
       
Ordering Information for Cryoarchived Strains - Order Form for Cryoarchived Strains

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