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Strain Number: 01XM2 
Common Strain Name: p53 LSL R172H 
Strain Nomenclature: 129S4-Trp53tm2Tyj/Nci 
 
Release Category (Required for MTA form): B3 , D
Sample MTA for this strain
Animal Health Report in PDF Format  
   
       
Strain Description: These mice contain a point-mutant allele of Trp53 that can be activated by Cre-mediated recombination. The conditional allele, containing LoxP sites and a transcriptional/translational STOP sequence, is functionally equivalent to a null mutation.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Transformation related protein 53
  Gene Symbol: Trp53
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: 129S4 
  Approx. Generation: 22 
  Organ Site :  
       
Husbandry: Heterozygous breeder pairs are provided. Homozygotes are viable and fertile but have decreased fertility and die young. Easiest to maintain as heterozygotes.
Genotyping Information: Protocol 1: Allele: Trp53  
       
Donating Investigator: Dr. Tyler  Jacks
Key Reference: Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60. PMID: 15607980 [PubMED Abstract]
     
       
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