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| Strain
Number: |
01XM3 |
| Common
Strain Name: |
p53 LSL R270H |
| Strain
Nomenclature: |
129S4-Trp53tm3Tyj |
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| Release
Category (Required for MTA form):
B,D
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| Animal Health Report in PDF Format |
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| Strain
Description: |
These mice contain a point-mutant allele of Trp53 that can be activated by Cre-mediated recombination. The conditional allele, containing LoxP sites and a transcriptional/translational STOP sequence, is functionally equivalent to a null mutation. |
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| Mutation
Information |
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Mutation
Type: |
Targeted |
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Gene
Name: |
Transformation related protein 53
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Gene
Symbol: |
Trp53
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Transgene
Name: |
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Transgene
Symbol: |
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Promoter
Name: |
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Promoter
Symbol: |
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Current
Genetic Background: |
129S4 |
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Approx.
Generation: |
8 |
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Organ
Site : |
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Cryopreservation Mating Scheme: |
129S4 females x heterozygous males |
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| Genotyping Information: |
Protocol 1: Allele: Trp53
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| Donating
Investigator: |
Dr. Tyler Jacks |
| Key
Reference: |
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60.
PMID: 15607980
[PubMED
Abstract]
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