| |
|
| |
|
| Strain
Number: |
01XP3 |
| Common
Strain Name: |
Apc Delta 580 |
| Strain
Nomenclature: |
STOCK-Apctm2.1Rak |
| |
|
|
| Release
Category (Required for MTA form):
B1
,
D
|
|
|
|
|
| |
|
|
|
| Strain
Description: |
This strain carries a germline targeted mutant allele of Apc in which exon14 has been removed by cre-mediated recombination, leading to expression of a truncated Apc protein of 605 amino acid residues (aa), of which the first 580 aa correspond to the normal protein. Heterozygous mice develop multiple intestinal neoplasias and die within 5 months of age. Homozygotes are embryonic lethal. Heterozygous females show nursing deficiency. |
| |
|
|
|
| Mutation
Information |
|
| |
Mutation
Type: |
Targeted |
| |
Gene
Name: |
Adenomatosis polyposis coli
|
| |
Gene
Symbol: |
Apc
|
| |
Transgene
Name: |
|
| |
Transgene
Symbol: |
|
| |
Promoter
Name: |
|
| |
Promoter
Symbol: |
|
| |
Current
Genetic Background: |
STOCK |
| |
Approx.
Generation: |
10 |
| |
Organ
Site : |
GI tract |
| |
|
|
|
|
Cryopreservation Mating Scheme: |
C57BL/6 females x heterozygous males |
|
| Genotyping Information: |
Protocol 1: Allele: Apc
|
| |
|
|
|
| Donating
Investigator: |
Dr. Raju Kucherlapati |
| Key
Reference: |
Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Adenomatous polyposis coli (Apc) is required for normal development of skin and thymus. PLoS Genetics 2, 1362-1374, 2006. PMID 17002498
[PubMED
Abstract]
|
| |
|
|
|
| |
|
|
|
|
