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Strain Number: 01XP3 
Common Strain Name: Apc Delta 580 
Strain Nomenclature: STOCK-Apctm2.1Rak/Nci 
 
Release Category (Required for MTA form): B1 , D
Sample MTA for this strain
   
       
Strain Description: This strain carries a germline targeted mutant allele of Apc in which exon14 has been removed by cre-mediated recombination, leading to expression of a truncated Apc protein of 605 amino acid residues (aa), of which the first 580 aa correspond to the normal protein. Heterozygous mice develop multiple intestinal neoplasias and die within 5 months of age. Homozygotes are embryonic lethal. Heterozygous females show nursing deficiency.
       
Mutation Information  
  Mutation Type: Targeted 
  Gene Name: Adenomatosis polyposis coli
  Gene Symbol: Apc
  Transgene Name:
  Transgene Symbol:
  Promoter Name:  
  Promoter Symbol:  
  Current Genetic Background: STOCK 
  Approx. Generation: 10 
  Organ Site : GI tract 
       
Cryopreservation Mating Scheme: C57BL/6 females x heterozygous males  
Genotyping Information: Protocol 1: Allele: Apc  
       
Donating Investigator: Dr. Raju  Kucherlapati
Key Reference: Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Adenomatous polyposis coli (Apc) is required for normal development of skin and thymus. PLoS Genetics 2, 1362-1374, 2006. PMID 17002498 [PubMED Abstract]
     
       
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